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Submission info:

Task mode - auto
Username:(not provided)Set of templates:inactive
Task token:002f76caea934074acb37c0d595e7a70Lysozyme included:no
Date of submission:02/05/18 07:33 PMBranch cutoff:0.01
Date finished:02/06/18 01:08 AMMin e-value:1e-100
Query length:319Max e-value:1e-10

Query sequence:
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Results:


MODE: Quick path

Template selection:
TemplateClustalW2 ScoreIdentityGlobal SimilaritySelectedViewDownload
human beta-adrenergic beta2AR-T4L - CIM (a et al., ?)
5D6L_A
2522.910.193YesViewDownload
undefined opioid Structural basis for bifunctional peptide recognition at human delta-opioid receptor. (enalti et al., 2015)
4RWA_A
2522.9810.186YesViewDownload
human, bacteriophage t4 opioid tructure of the human kappa-opioid receptor in complex with JDTic (u et al., 2012)
4DJH_A
2522.7690.193NoViewDownload
human beta2-adrenergic 'High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.' (Cherezov et al., 2007)
2RH1_A
2522.910.185NoViewDownload
human beta-adrenergic Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. (taus et al., 2016)
5JQH_A
2422.910.186NoViewDownload
undefined opioid Structural basis for bifunctional peptide recognition at human delta-opioid receptor. (enalti et al., 2015)
4RWD_A
2522.9810.177NoViewDownload
human opioid Molecular control of delta-opioid receptor signalling. (enalti et al., 2014)
4N6H_A
2523.2920.173NoViewDownload
undefined opioid Structure of the delta opioid receptor bound to naltrindole (ranier et al., 2012)
4EJ4_A
2522.360.178NoViewDownload
undefined nociceptin The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor. (iller et al., 2015)
5DHH_A
2521.8750.177NoViewDownload
turkey beta-adrenergic Ligand occupancy in crystal structure of Beta1 adrenergic G protein coupled receptor (eslie et al., 2015)
5F8U_A
2421.6720.181NoViewDownload
turkey beta1-adrenergic 'Structure of a Beta1-Adrenergic G-Protein-Coupled Receptor.' (Warne et al., 2008)
2VT4_B
2421.6720.181NoViewDownload
undefined nociceptin Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. (hompson et al., 2012)
4EA3_A
2521.5630.174NoViewDownload
human nociceptin The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor. (iller et al., 2015)
5DHG_A
2521.5630.173NoViewDownload
human dopamine 'Structure of the human dopamine d3 receptor in complex with a d2/d3 selective antagonist.' (Chien et al., 2010)
3PBL_A
2721.5380.162NoViewDownload
mouse, bacteriophage t4 opioid Crystal structure of the {mu}-opioid receptor bound to a morphinan antagonist. (anglik et al., 2012)
4DKL_A
2420.8070.172NoViewDownload
human angiotensin-AT2R Structural Basis for Selectivity and Functional Diversity in Angiotensin II Receptors (hang et al., 2017)
5UNG_B
2321.0370.153NoViewDownload
human angiotensin-AT1R Structure of the Angiotensin receptor revealed by serial femtosecond crystallography. (hang et al., 2015)
4YAY_A
2319.8780.147NoViewDownload
undefined chemokine_CXC Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. (in et al., 2015)
4RWS_A
2320.1830.136NoViewDownload
bovine rhodopsin Crystal structure of metarhodopsin II. (hoe et al., 2011)
3PQR_A
2219.5910.145NoViewDownload
bovine rhodopsin 'The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure' (Okada et al., 2004)
1U19_A
2219.1550.142NoViewDownload
human adenosine Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket. (un et al., 2017)
5UIG_A
2420.00.116NoViewDownload
brown rat,rat,rats muscarinic Structure and dynamics of the M3 muscarinic acetylcholine receptor. (ruse et al., 2012)
4DAJ_A
2518.8270.14NoViewDownload
human adenosine Structural basis for allosteric regulation of GPCRs by sodium ions. (iu et al., 2012)
4EIY_A
2319.760.121NoViewDownload
human chemokine_CC Intracellular allosteric antagonism of the CCR9 receptor. (swald et al., 2016)
5LWE_A
2219.4530.127NoViewDownload
human angiotensin-AT1R Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor. (hang et al., 2015)
4ZUD_A
2318.5980.141NoViewDownload
human chemokine_CC Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. (heng et al., 2016)
5T1A_A
2419.0180.127NoViewDownload
undefined endothelin Activation mechanism of endothelin ETB receptor by endothelin-1. (hihoya et al., 2016)
5GLI_A
1920.120.116NoViewDownload
human purinergic_P2Y1 Two disparate ligand-binding sites in the human P2Y1 receptor (hang et al., 2015)
4XNW_A
2018.7880.138NoViewDownload
human adenosine Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength. (egala et al., 2016)
5IU4_A
2319.4610.115NoViewDownload
human adenosine 'The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist.' (Jaakola et al., 2008)
3EML_A
2219.5720.109NoViewDownload
human purinergic_P2Y1 Two disparate ligand-binding sites in the human P2Y1 receptor (hang et al., 2015)
4XNV_A
2018.4850.133NoViewDownload
undefined endothelin Activation mechanism of endothelin ETB receptor by endothelin-1. (hihoya et al., 2016)
5GLH_A
1919.0330.117NoViewDownload
undefined muscarinic Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. (aga et al., 2012)
3UON_A
2118.210.132NoViewDownload
undefined chemokine_CC Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. (an et al., 2013)
4MBS_A
2018.7120.125NoViewDownload
human histamine 'Structure of the human histamine H1 receptor complex with doxepin.' (Shimamura et al., 2011)
3RZE_A
2218.0690.126NoViewDownload
human cannabinoid Crystal Structure of the Human Cannabinoid Receptor CB1. (ua et al., 2016)
5TGZ_A
2018.8850.088NoViewDownload
human cannabinoid High-resolution crystal structure of the human CB1 cannabinoid receptor. (hao et al., 2016)
5U09_A
1718.8850.089NoViewDownload
human purinergic_P2Y12 Structure of the human P2Y12 receptor in complex with an antithrombotic drug (hang et al., 2014)
4NTJ_A
1915.7410.08NoViewDownload
human purinergic_P2Y12 Agonist-bound structure of the human P2Y12 receptor (hang et al., 2014)
4PY0_A
1716.00.076NoViewDownload
human, virus sphingosine Crystal structure of a lipid G protein-coupled receptor. (anson et al., 2012)
3V2Y_A
1917.2210.052NoViewDownload
human purinergic_P2Y12 Agonist-bound structure of the human P2Y12 receptor (hang et al., 2014)
4PXZ_A
1815.9510.071NoViewDownload
human lysophosphatidic-acid Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1. (hrencik et al., 2015)
4Z35_A
1814.8480.053NoViewDownload
human lysophosphatidic-acid Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1. (hrencik et al., 2015)
4Z34_A
1814.7150.052NoViewDownload
human lysophosphatidic-acid Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1. (hrencik et al., 2015)
4Z36_A
1814.8480.049NoViewDownload
human glutamate5 Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile). (hristopher et al., 2015)
5CGD_A
1212.538-0.006NoViewDownload
human glutamate5 Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile). (hristopher et al., 2015)
5CGC_A
1212.538-0.007NoViewDownload
human, t4 phage, human glutamate5 Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain. (ore et al., 2014)
4OO9_A
1311.692-0.017NoViewDownload
human glucagon-like Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators (ong et al., 2017)
5VEX_A
1611.25-0.022NoViewDownload
human corticotropin Structure of class B GPCR corticotropin-releasing factor receptor 1. (ollenstein et al., 2013)
4K5Y_A
1212.226-0.028NoViewDownload
human glucagon-like Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. (ong et al., 2017)
5VEW_A
1611.25-0.022NoViewDownload
human corticotropin Decoding Corticotropin-Releasing Factor Receptor Type 1 Crystal Structures (ore et al., ?)
4Z9G_A
1111.912-0.045NoViewDownload
human glucagon-like Crystal structure of the GLP-1 receptor bound to a peptide agonist. (azayeri et al., 2017)
5NX2_A
119.602-0.019NoViewDownload
human glutamate1 Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator (u et al., 2014)
4OR2_A
89.816-0.034NoViewDownload
human glucagon Structure of the human glucagon class B G-protein-coupled receptor. (iu et al., 2013)
4L6R_A
610.559-0.034NoViewDownload
human glucagon Extra-helical binding site of a glucagon receptor antagonist. (azayeri et al., 2016)
5EE7_A
89.317-0.017NoViewDownload
undefined smoothened Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. (ang et al., 2014)
4QIN_A
79.756-0.065NoViewDownload
rabbit glucagon Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. (hang et al., 2017)
5VAI_R
108.645-0.036NoViewDownload
undefined smoothened Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. (ang et al., 2014)
4N4W_A
69.73-0.067NoViewDownload
human smoothened Structure of the human smoothened receptor bound to an antitumour agent. (ang et al., 2013)
4JKV_A
79.459-0.07NoViewDownload
human glucagon Structure of the full-length glucagon class B G-protein-coupled receptor. (hang et al., 2017)
5XF1_A
77.728-0.046NoViewDownload
human glucagon Structure of the Full-length glucagon class B G protein-coupled receptor (hang et al., 2017)
5XEZ_A
77.728-0.046NoViewDownload
undefined smoothened Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. (ang et al., 2014)
4QIM_A
78.971-0.074NoViewDownload
undefined smoothened Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography. (eierstall et al., 2014)
4O9R_A
78.943-0.073NoViewDownload
human smoothened_N-domain Structural basis of Smoothened regulation by its extracellular domains. (yrne et al., 2016)
5L7I_A
86.574-0.09NoViewDownload
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Alignments generated with selected templates:
TemplateAlignment MethodIdentityGlobal SimilarityNon-anchored alignmentAnchored AlignmentNon-anchored AlignmentAnchored AlignmentSelected
human beta-adrenergic beta2AR-T4L - CIM (a et al., ?)
5D6L_A
structure-based21.8840.186-View-DownloadYes
human beta-adrenergic beta2AR-T4L - CIM (a et al., ?)
5D6L_A
profile-profile20.1780.159ViewViewDownloadDownloadNo
human beta-adrenergic beta2AR-T4L - CIM (a et al., ?)
5D6L_A
multiple SA21.5150.175ViewViewDownloadDownloadNo
human beta-adrenergic beta2AR-T4L - CIM (a et al., ?)
5D6L_A
simple pairwise SA21.8840.186ViewViewDownloadDownloadNo
undefined opioid Structural basis for bifunctional peptide recognition at human delta-opioid receptor. (enalti et al., 2015)
4RWA_A
structure-based18.7680.152-View-DownloadYes
undefined opioid Structural basis for bifunctional peptide recognition at human delta-opioid receptor. (enalti et al., 2015)
4RWA_A
profile-profile22.1540.187ViewViewDownloadDownloadNo
undefined opioid Structural basis for bifunctional peptide recognition at human delta-opioid receptor. (enalti et al., 2015)
4RWA_A
multiple SA22.9810.183ViewViewDownloadDownloadNo
undefined opioid Structural basis for bifunctional peptide recognition at human delta-opioid receptor. (enalti et al., 2015)
4RWA_A
simple pairwise SA23.0530.189ViewViewDownloadDownloadNo
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Final Alignment:
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Final Alignment in the PIR format:
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Loops to be refined (Modeller):
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Generated Modeller Models:
PDB file:Model DOPE ScoreLoop DOPE ScoreModel ViewerDownload PDB
gpcrm_model_01.pdb-40514.35547-9956.25879NGL JSmolDownload
gpcrm_model_02.pdb-40191.58203-8894.68164NGL JSmolDownload
gpcrm_model_03.pdb-39875.95703-8908.85449NGL JSmolDownload
gpcrm_model_04.pdb-39578.95703-8904.20801NGL JSmolDownload
gpcrm_model_05.pdb-38736.89844-8872.54785NGL JSmolDownload
gpcrm_model_06.pdb-38646.92578-8288.46582NGL JSmolDownload
gpcrm_model_07.pdb-38247.96484-9551.97754NGL JSmolDownload
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Loops to be refined (Rosetta):
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Generated Rosetta Models:
PDB file:Model DOPE ScoreLoop DOPE ScoreRosetta ScoreModel ViewerDownload PDB
gpcrm_model_r01.pdb-40191.58203-8894.68164355.977NGL JSmolDownload
gpcrm_model_r02.pdb-40191.58203-8894.68164376.061NGL JSmolDownload
gpcrm_model_r03.pdb-39578.95703-8904.20801378.64NGL JSmolDownload
gpcrm_model_r04.pdb-40514.35547-9956.25879389.551NGL JSmolDownload
gpcrm_model_r05.pdb-40514.35547-9956.25879401.785NGL JSmolDownload
gpcrm_model_r06.pdb-39578.95703-8904.20801422.417NGL JSmolDownload
gpcrm_model_r07.pdb-39578.95703-8904.20801440.13NGL JSmolDownload
gpcrm_model_r08.pdb-39875.95703-8908.85449444.355NGL JSmolDownload
gpcrm_model_r09.pdb-39875.95703-8908.85449447.93NGL JSmolDownload
gpcrm_model_r10.pdb-40514.35547-9956.25879471.762NGL JSmolDownload
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Sequences in the query profile. Sequences are sorted by e-value in descending order. The first sequence in the file is your query sequence.
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Anchored realignment - a log file.
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Modeller run script (1)
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Modeller run script (2)
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Modeller Run - a log file.
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Rosetta Run - a log file.
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Alignments & Models - zip file.
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